For article metrics see my google scholar profile.

2023

  • Breeuwsma, M., & Heesters, B. A. (2023). Protocol for the Isolation and Purification of Human Follicular Dendritic Cells for Functional Assays. STAR Protocols, 4(3), 102404. https://doi.org/10.1016/j.xpro.2023.102404
  • Tomris, I., Unione, L., Nguyen, L., Zaree, P., Bouwman, K. M., Liu, L., Li, Z., Fok, J. A., Ríos Carrasco, M., van der Woude, R., Kimpel, A. L. M., Linthorst, M. W., Kilavuzoglu, S. E., Verpalen, E. C. J. M., Caniels, T. G., Sanders, R. W., Heesters, B. A., Pieters, R. J., Jiménez-Barbero, J., … de Vries, R. P. (2023). SARS-CoV-2 Spike N-Terminal Domain Engages 9-O-Acetylated A2–8-Linked Sialic Acids. ACS Chemical Biology. https://doi.org/10.1021/acschembio.3c00066

2022

  • Küçükköse, E., Heesters, B. A., Villaudy, J., Verheem, A., Cercel, M., van Hal, S., Boj, S. F., Rinkes, I. H. M. B., Punt, C. J. A., Roodhart, J. M. L., Laoukili, J., Koopman, M., Spits, H., & Kranenburg, O. (2022). Modeling Resistance of Colorectal Peritoneal Metastases to Immune Checkpoint Blockade in Humanized Mice. Journal for ImmunoTherapy of Cancer, 10(12), e005345. https://doi.org/10.1136/jitc-2022-005345

2021

  • Krabbendam, L., Heesters, B. A., Kradolfer, C. M. A., Haverkate, N. J. E., Becker, M. a. J., Buskens, C. J., Bemelman, W. A., Bernink, J. H., & Spits, H. (2021). CD127+ CD94+ Innate Lymphoid Cells Expressing Granulysin and Perforin Are Expanded in Patients with Crohn’s Disease. Nature Communications, 12(1), 1–11. https://doi.org/10.1038/s41467-021-26187-x
  • Heesters, B. A., van Megesen, K., Tomris, I., de Vries, R. P., Magri, G., & Spits, H. (2021). Characterization of Human FDCs Reveals Regulation of T Cells and Antigen Presentation to B Cells. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20210790
  • Krabbendam, L., Heesters, B. A., Kradolfer, C. M. A., Spits, H., & Bernink, J. H. (2021). Identification of Human Cytotoxic ILC3s. European Journal of Immunology, 51(4), 811–823. https://doi.org/10.1002/eji.202048696
  • Golebski, K., Layhadi, J. A., Sahiner, U., Steveling-Klein, E. H., Lenormand, M. M., Li, R. C. Y., Bal, S. M., Heesters, B. A., Vilà-Nadal, G., Hunewald, O., Montamat, G., He, F. Q., Ollert, M., Fedina, O., Lao-Araya, M., Vijverberg, S. J. H., der Zee, A.-H. M.-van, van Drunen, C. M., Fokkens, W. J., … Shamji, M. H. (2021). Induction of IL-10-producing Type 2 Innate Lymphoid Cells by Allergen Immunotherapy Is Associated with Clinical Response. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2020.12.013
  • van der Ploeg, E. K., Golebski, K., van Nimwegen, M., Fergusson, J. R., Heesters, B. A., Martinez-Gonzalez, I., Kradolfer, C. M. A., van Tol, S., Scicluna, B. P., de Bruijn, M. J. W., de Boer, G. M., Tramper-Stranders, G. A., Braunstahl, G.-J., van IJcken, W. F. J., Nagtegaal, A. P., van Drunen, C. M., Fokkens, W. J., Huylebroeck, D., Spits, H., … Bal, S. M. (2021). Steroid-Resistant Human Inflammatory ILC2s Are Marked by CD45RO and Elevated in Type 2 Respiratory Diseases. Science Immunology, 6(55). https://doi.org/10.1126/sciimmunol.abd3489

2020

  • Genzel, L., Adan, R., Berns, A., van den Beucken, J., Blokland, A., Boddeke, E. H. W. G. M., Bogers, W. M., Bontrop, R., Bulthuis, R., Bousema, T., Clevers, H., Coenen, T. C. J. J., van Dam, A.-M., Deen, P. M. T., van Dijk, K. W., Eggen, B. J. L., Elgersma, Y., Erdogan, I., Englitz, B., … Homberg, J. R. (2020). How the COVID-19 Pandemic Highlights the Necessity of Animal Research. Current Biology, 30(18), R1014–R1018. https://doi.org/10.1016/j.cub.2020.08.030

2019

  • Nagasawa, M., Heesters, B. A., Kradolfer, C. M. A., Krabbendam, L., Martinez-Gonzalez, I., de Bruijn, M. J. W., Golebski, K., Hendriks, R. W., Stadhouders, R., Spits, H., & Bal, S. M. (2019). KLRG1 and NKp46 Discriminate Subpopulations of Human CD117+CRTH2- ILCs Biased toward ILC2 or ILC3. Journal of Experimental Medicine, jem.20190490. https://doi.org/10.1084/jem.20190490
  • Golebski, K., Ros, X. R., Nagasawa, M., van Tol, S., Heesters, B. A., Aglmous, H., Kradolfer, C. M. A., Shikhagaie, M. M., Seys, S., Hellings, P. W., van Drunen, C. M., Fokkens, W. J., Spits, H., & Bal, S. M. (2019). IL-1β, IL-23, and TGF-β Drive Plasticity of Human ILC2s towards IL-17-producing ILCs in Nasal Inflammation. Nature Communications, 10(1), 2162. https://doi.org/10.1038/s41467-019-09883-7
  • Willemze, R. A., Welting, O., van Hamersveld, P., Verseijden, C., Nijhuis, L. E., Hilbers, F. W., Meijer, S. L., Heesters, B. A., Folgering, J. H. A., Darwinkel, H., Blancou, P., Vervoordeldonk, M. J., Seppen, J., Heinsbroek, S. E. M., & de Jonge, W. J. (2019). Loss of Intestinal Sympathetic Innervation Elicits an Innate Immune Driven Colitis. Molecular Medicine, 25(1), 1. https://doi.org/10.1186/s10020-018-0068-8

2018

  • Fergusson, J. R., Morgan, M. D., Bruchard, M., Huitema, L., Heesters, B. A., van Unen, V., van Hamburg, J. P., van der Wel, N. N., Picavet, D., Koning, F., Tas, S. W., Anderson, M. S., Marioni, J. C., Holländer, G. A., & Spits, H. (2018). Maturing Human CD127+ CCR7+ PDL1+ Dendritic Cells Express AIRE in the Absence of Tissue Restricted Antigens. Frontiers in Immunology, 9, 2902. https://doi.org/10.3389/fimmu.2018.02902

2017

  • Garrison, B. S., Rybak, A. P., Beerman, I., Heesters, B. A., Mercier, F. E., Scadden, D. T., Bryder, D., Baron, R., & Rossi, D. J. (2017). ZFP521 Regulates Murine Hematopoietic Stem Cell Function and Facilitates MLL-AF9 Leukemogenesis in Mouse and Human Cells. Blood, 130(5), 619–624. https://doi.org/10.1182/blood-2016-09-738591
  • Das, A., Heesters, B. A., Bialas, A., O’Flynn, J., Rifkin, I. R., Ochando, J., Mittereder, N., Carlesso, G., Herbst, R., & Carroll, M. C. (2017). Follicular Dendritic Cell Activation by TLR Ligands Promotes Autoreactive B Cell Responses. Immunity, 46(1), 106–119. https://doi.org/10.1016/j.immuni.2016.12.014
  • Heesters, B. A., van der Poel, C. E., & Carroll, M. C. (2017). Follicular Dendritic Cell Isolation and Loading of Immune Complexes. Germinal Centers: Methods and Protocols, 105–112. https://doi.org/10.1007/978-1-4939-7095-7_9

2016

  • Claessen, F. M. A. P., Heesters, B. A., Chan, J. J., Kachooei, A. R., & Ring, D. (2016). A Meta-Analysis of the Effect of Corticosteroid Injection for Enthesopathy of the Extensor Carpi Radialis Brevis Origin. The Journal of Hand Surgery, 41(10), 988–998. https://doi.org/10.1016/j.jhsa.2016.07.097
  • Heesters, B. A., van der Poel, C. E., Das, A., & Carroll, M. C. (2016). Antigen Presentation to B Cells. Trends in Immunology, 37(12), 844–854. https://doi.org/10.1016/j.it.2016.10.003
  • Heesters, B. A., & Carroll, M. C. (2016). The Role of Dendritic Cells in S. Pneumoniae Transport to Follicular Dendritic Cells. Cell Reports, 16(12), 3130–3137. https://doi.org/10.1016/j.celrep.2016.08.049

2015

  • Langereis, M. A., Bakkers, M. J. G., Deng, L., Padler-Karavani, V., Vervoort, S. J., Hulswit, R. J. G., van Vliet, A. L. W., Gerwig, G. J., de Poot, S. A. H., Boot, W., van Ederen, A. M., Heesters, B. A., van der Loos, C. M., van Kuppeveld, F. J. M., Yu, H., Huizinga, E. G., Chen, X., Varki, A., Kamerling, J. P., & de Groot, R. J. (2015). Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins. Cell Reports, 11(12), 1966–1978. https://doi.org/10.1016/j.celrep.2015.05.044
  • Mooster, J. L., Le Bras, S., Massaad, M. J., Jabara, H., Yoon, J., Galand, C., Heesters, B. A., Burton, O. T., Mattoo, H., Manis, J., & Geha, R. S. (2015). Defective Lymphoid Organogenesis Underlies the Immune Deficiency Caused by a Heterozygous S32I Mutation in I\kappaBα. Journal of Experimental Medicine, 212(2), 185–202. https://doi.org/10.1084/jem.20140979
  • Heesters, B. A. (2015). Antigen Dynamics of Follicular Dendritic Cells [PhD thesis]. Harvard University & Utrecht University.
  • Heesters, B. A., Lindqvist, M., Vagefi, P. A., Scully, E. P., Schildberg, F. A., Altfeld, M., Walker, B. D., Kaufmann, D. E., & Carroll, M. C. (2015). Follicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes. PLoS Pathogens, 11(12), e1005285. https://doi.org/10.1371/journal.ppat.1005285

2014

  • Zhao, F., Heesters, B. A., Chiu, I., Gao, Y., Shi, J., Zhou, N., Carroll, M. C., & Xu, B. (2014). L-Rhamnose-containing Supramolecular Nanofibrils as Potential Immunosuppressive Materials. Organic & Biomolecular Chemistry, 12(35), 6816–6819. https://doi.org/10.1039/c4ob01362j
  • Woodruff, M. C., Heesters, B. A., Herndon, C. N., Groom, J. R., Thomas, P. G., Luster, A. D., Turley, S. J., & Carroll, M. C. (2014). Trans-Nodal Migration of Resident Dendritic Cells into Medullary Interfollicular Regions Initiates Immunity to Influenza Vaccine. Journal of Experimental Medicine, 211(8), 1611–1621. https://doi.org/10.1084/jem.20132327
  • Heesters, B. A., Das, A., Chatterjee, P., & Carroll, M. C. (2014). Do Follicular Dendritic Cells Regulate Lupus-Specific B Cells? Molecular Immunology, 62(2), 283–288. https://doi.org/10.1016/j.molimm.2014.02.010
  • Heesters, B. A., Myers, R. C., & Carroll, M. C. (2014). Follicular Dendritic Cells: Dynamic Antigen Libraries. Nature Reviews Immunology, 14(7), 495–504. https://doi.org/10.1038/nri3689

2013

  • Chiu, I. M., Heesters, B. A., Ghasemlou, N., Von Hehn, C. A., Zhao, F., Tran, J., Wainger, B., Strominger, A., Muralidharan, S., Horswill, A. R., & others. (2013). Bacteria Activate Sensory Neurons That Modulate Pain and Inflammation. Nature, 501(7465), 52–57. https://doi.org/10.1038/nature12479
  • Heesters, B. A., Chatterjee, P., Kim, Y.-A., Gonzalez, S. F., Kuligowski, M. P., Kirchhausen, T., & Carroll, M. C. (2013). Endocytosis and Recycling of Immune Complexes by Follicular Dendritic Cells Enhances B Cell Antigen Binding and Activation. Immunity, 38(6), 1164–1175. https://doi.org/10.1016/j.immuni.2013.02.023
  • Woodruff, M. C., Herndon, C. N., Heesters, \relax B. A., & Carroll, M. C. (2013). Contextual Analysis of Immunological Response through Whole-Organ Fluorescent Imaging. Lymphatic Research and Biology, 11(3), 121–127. https://doi.org/10.1089/lrb.2013.0011

2012

  • Langereis, M. A., Zeng, Q., Heesters, B. A., Huizinga, E. G., & de Groot, R. J. (2012). The Murine Coronavirus Hemagglutinin-Esterase Receptor-Binding Site: A Major Shift in Ligand Specificity through Modest Changes in Architecture. PLoS Pathogens, 8(1), e1002492. https://doi.org/10.1371/journal.ppat.1002492

2011

  • Gonzalez, S. F., Degn, S. E., Pitcher, L. A., Woodruff, M., Heesters, B. A., & Carroll, M. C. (2011). Trafficking of B Cell Antigen in Lymph Nodes. Annual Review of Immunology, 29(1), 215–233. https://doi.org/10.1146/annurev-immunol-031210-101255

2010

  • Heesters, B. A. (2010). Complement Evasion Strategies of Bacteria, Viruses, Fungi and Parasites [Master's thesis]. Utrecht University.

In the News

Thirteen Utrecht-based researchers receive Vidi grant
Utrecht University website, June 2023

97 leading researchers receive Vidi grants
NWO website news, June 2023

Twenty-six groundbreaking research projects awarded via the Open Competition Domain Science – XS
NWO website news, November 2022

Inflammation Network with keynote lecture from Balthasar Heesters on follicular dendritic cells.
Aarhus University news, August 2022

Infection and Immunology Seminar with Balthasar Heesters: “Follicular dendritic cells; neglected regulators”.
Karolinska news, October 2021

Veni grants for 17 UvA and AMC researchers.
University of Amsterdam news, July 2017

Infectiebacterie prikkelt zelf de pijnzenuw. (Dutch)
NRC Handelsblad, August 2013

Can bacteria use pain to tamp down the immune system?
Chicago Tribune, August 2013